Matlacha (pronounced "MAT-la-shay") is a census-designated place (CDP) in Lee County, Florida, United States. As of the 2000 census, the CDP had a total population of 735. It is part of the Cape Coral–Fort Myers Metropolitan Statistical Area. The community's name comes from a Caloosa word meaning "water to the chin."
Matlacha is one of five communities on Pine Island, although technically, it is located on a smaller island in Matlacha Pass, east of Pine Island. It is an "Old Florida" fishing village home to many brightly-colored art galleries, island boutiques, seafood restaurants, and traditional Florida cottages.
Matlacha is located at 26°37′49″N 82°4′24″W / 26.63028°N 82.07333°W / 26.63028; -82.07333 (26.630339, -82.073412).