Keosauqua ( /ˌkiːəsɔːkwə/ kee-ə-saw-kwə) is a city in Van Buren County, Iowa, United States. The population was 1,066 at the 2000 census. It is the county seat of Van Buren County.
The word Keosauqua derives from the Meskwaki and Sauk name for the Des Moines River, "Ke-o-saw-qua", which literally translates as "Bend in the River". The Hotel Manning, a three story relic from the Des Moines River's steamboat days, is Keosauqua's most notable landmark. Also located in Keosauqua are many other notable historic sites. The 1847 Pearson House was a stop on the underground railroad.
The Honey War was fought south of Keosauqua in what is now Lacey-Keosauqua State Park. Lacey-Keosauqua is one of the largest state parks in Iowa and was built by the Civil Conservation Corps during the Great Depression. Keosauqua hosts its annual Fall Festival the second full weekend in October.