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Melrose is a city in Monroe County, Iowa, United States. The population was 130 at the 2000 census. Melrose is known as Iowa's "Little Ireland". As such, the majority of the 130 population are Irish Catholics.
According to the United States Census Bureau, the city has a total area of 0.9 square miles (2.2 km²), all of it land.
As of the census of 2000, there were 130 people, 56 households, and 38 families residing in the city. The population density was 153.7 people per square mile (59.1/km²). There were 67 housing units at an average density of 79.2 per square mile (30.4/km²). The racial makeup of the city was 97.69% White, 0.77% Asian, 0.77% from other races, and 0.77% from two or more races.