Muscatine is a city in Muscatine County, Iowa, United States. The population was 22,886 in the 2010 census, an increase from 22,697 in the 2000 census. It is the county seat of Muscatine County. The name Muscatine is unusual in that it is not used by any other city in the United States.
Muscatine is the principal city of the Muscatine Micropolitan Statistical Area (2000 census population 53,905), which includes all of Muscatine and Louisa counties.
Muscatine began as a trading post founded by representatives of Colonel George Davenport in 1833. Muscatine was incorporated as Bloomington in 1839, but the name was changed to reduce mail delivery confusion as there were several Bloomingtons in the Midwest. Before that, Muscatine had also been known as "Casey's Woodpile".