Osceola is a city in Clarke County, Iowa, United States. The population was 4,659 at the 2000 census. It is the county seat of Clarke County.
Osceola is located at 41°2′3″N 93°46′6″W / 41.03417°N 93.76833°W / 41.03417; -93.76833 (41.034179, -93.768354), at the junction of Interstate 35 and U.S. Routes 34 and 69. It lies 35 miles (56 km) north of the Missouri border.
According to the United States Census Bureau, the city has a total area of 6.0 square miles (15.6 km²), of which, 5.8 square miles (15.1 km²) of it is land and 0.2 square miles (0.5 km²) of it (3.31%) is water.