Brussels is a village in Calhoun County, Illinois, United States. The population was 141 at the 2000 census.
Brussels is the headquarters location of the Two Rivers National Wildlife Refuge, which is noted for its population of bald eagles. The refuge is named after the two great rivers that flow together close to Brussels, the Illinois River and the Mississippi River.
Brussels has one school district, No. 42, which consists of one grade school (Brussels Grade School) and one high school (Brussels High School). The school district serves the surrounding communities of Meppen, Golden Eagle, and parts of Batchtown. In addition to the public school system, Brussels has a parochial grade school, St. Marys. Brussels High School is small and its enrollment usually hovers at around 70 students.