Effingham is a city in Effingham County, Illinois, United States. The population was 12,384 at the 2000 census. It is the county seat of Effingham County.
The city bills itself as "The Crossroads of Opportunity" because of its location at the intersection of two major Interstate highways: I-57 running from Chicago to Miner, Missouri, and I-70 running from Utah to Maryland. It also is the path of U.S. Route 45, which runs from Michigan to Alabama. Illinois Route 33 and Illinois Route 32 also run through the city. Thus, Effingham has a broad range of restaurants, lodging, and shopping facilities. Effingham is also located on U.S. Highway 40, the historic National Road, which stretches from Cumberland, Maryland to East St. Louis, Illinois.
Effingham is located at 39°7′15″N 88°32′45″W / 39.12083°N 88.54583°W / 39.12083; -88.54583 (39.120903, -88.545909).