Kampsville is a village in Calhoun County, Illinois, United States, located on the west bank of the Illinois River. The population was 350 at the 2000 census.
The Kampsville ferry operates across the Illinois River and connects the Kampsville segment of Illinois Route 108 with its remainder in Greene County. The ferry is free and runs 24 hours a day, seven days a week. It is one of two permanent ferries operated by the Illinois Department of Transportation.
The village is the base of operations for the Center for American Archeology, an educational and research organization dedicated to the archeological understanding of the Native Americans and of the European settlers in the region. It contains exhibits demonstrating evidence of 7,000 years of human habitation excavated at the Koster Site in nearby Greene County, Illinois.