Oquawka is a village in Henderson County, Illinois, United States. The population was 1,539 at the 2000 census. It is the county seat of Henderson County.
Oquawka is part of the Burlington, IA–IL Micropolitan Statistical Area.
Oquawka is located at 40°56′20″N 90°56′57″W / 40.93889°N 90.94917°W / 40.93889; -90.94917 (40.938880, -90.949044).