Mitchell is a city in Lawrence County, Indiana, United States. The population was 4,567 as of the 2000 census.
It is the birthplace of astronaut Gus Grissom, who flew on Liberty Bell 7, Gemini 3, and died in a launch pad fire at Kennedy Space Center in 1967.
Mitchell was built as a railroad town in the mid-19th century. At this location in Lawrence County, the Chicago, Indianapolis and Louisville Railroad, better known by the shorter name of "the Monon", was built as a north-south line from New Albany to Chicago, passing through the area which became Mitchell in 1853. In 1857, the east-west Ohio and Mississippi Railway (later part of the Baltimore and Ohio Railroad) was completed, as part of a link between Cincinnati and St. Louis.