Isabel is a city in Barber County, Kansas, United States. As of the 2010 census, the city population was 90.
Isabel is located at 37°28′7″N 98°33′5″W / 37.46861°N 98.55139°W / 37.46861; -98.55139 (37.468706, -98.551325). According to the United States Census Bureau, the city has a total area of 0.2 square miles (0.6 km²), all of it land.
As of the census of 2000, there were 108 people, 46 households, and 31 families residing in the city. The population density was 429.9 people per square mile (166.8/km²). There were 53 housing units at an average density of 211.0 per square mile (81.9/km²). The racial makeup of the city was 93.52% White, 1.85% African American, 0.93% Native American, 0.93% from other races, and 2.78% from two or more races. Hispanic or Latino of any race were 0.93% of the population.