Holcomb is a city in Finney County, Kansas, United States. The population was 2,026 at the 2000 census.
Holcomb is known for the murders of four members of the Herbert W. Clutter family, an incident which formed the basis of the Truman Capote book In Cold Blood.
Holcomb is located at 37°59′2″N 100°59′10″W / 37.98389°N 100.98611°W / 37.98389; -100.98611 (37.983934, -100.985996). According to the United States Census Bureau, the city has a total area of 1.2 square miles (3.0 km²), all of it land.