Lyons is a city in and the county seat of Rice County, Kansas, United States. As of the 2010 census, the city population was 3,739.
Although Coronado's exact route across the plains is uncertain and has been widely disputed, he and his men are thought to have camped near the present location of Lyons on their quest for Quivira, a Native American place which Indians to the southwest had told them was fabulously wealthy in gold. West of Lyons is a cross commemorating Juan de Padilla, a member of Coronado's expedition, who returned the following year as a missionary. He was killed in 1542 by Native Americans after establishing a church in the area, and is considered the first Christian martyr in North America.
Lyons Main Street (U.S. Highway 56) is based on the Santa Fe Trail.