Syracuse is a city in and the county seat of Hamilton County, Kansas, United States. As of the 2010 census, the city population was 1,812.
Syracuse is located at 37°58′59″N 101°45′04″W / 37.982938°N 101.751224°W / 37.982938; -101.751224 (37.982938, -101.751224), along U.S. Route 50 sixteen miles (twenty-six kilometers) from the Colorado border. The Arkansas River runs just south of the City of Syracuse. The countryside south of the Arkansas River is marked by sandhills. Located within these sandhills is the "Syracuse Sand Dunes," a city park covering 1,300 acres (5.3 km2), including a 40-acre (160,000 m2) fishing pond.
According to the United States Census Bureau, the city has a total area of 1.3 square miles (3.4 km2), all land.