Wellsville is a city in Franklin County, Kansas, United States. The town site of Wellsville was laid out in the fall of 1864 by Messrs, Shoot, Root, and Wells of Chicago. The town was named after Mr. Wells of the company. The population was 1,606 at the 2000 census.
Wellsville is located at 38°43′11″N 95°4′53″W / 38.71972°N 95.08139°W / 38.71972; -95.08139 (38.719694, -95.081358). According to the United States Census Bureau, the city has a total area of 0.8 square miles (2.2 km²), all of it land.
As of the census of 2000, there were 1,606 people, 636 households, and 435 families residing in the city. The population density was 1,917.2 people per square mile (738.2/km²). There were 666 housing units at an average density of 795.1 per square mile (306.1/km²). The racial makeup of the city was 98.13% White, 0.19% African American, 0.50% Native American, 0.06% Asian, 0.06% from other races, and 1.06% from two or more races. Hispanic or Latino of any race were 0.75% of the population.