Brandenburg is a city in Meade County, Kentucky, United States, along the Ohio River. The population was 2,049 at the 2000 census. It is the county seat of Meade County.
Brandenburg was built on a 3,000-acre (12 km2) tract of land called Falling Springs, purchased in 1804 by Solomon Brandenburg. He opened a tavern around which the community grew, and in 1825 the community became the county seat, but the settlement didn't incorporate until March 28, 1872.
Brandenburg was devastated by an F5 tornado during the Super Outbreak of April 3, 1974; 31 were killed in the city.