Clarkson is a city in Grayson County, Kentucky, United States. The population was 794 at the 2000 census. Once called Grayson Springs after a nearby resort, the name was changed in 1882 to honor the resort's owner, Manoah Clarkson. It is known for its Honeyfest and is home to the The Walter T. Kelley Company, a manufacturer of beekeeping equipment.
Clarkson is located directly east of Leitchfield along U.S. Route 62 and the Western Kentucky Parkway.
According to the United States Census Bureau, the city has a total area of 0.6 square miles (1.6 km2), all of it land.