Guthrie is a city in Todd County, Kentucky, United States. The population was 1,469 at the 2000 census. The city is named for James Guthrie, president of the Louisville and Nashville Railroad when the city was incorporated in 1867.
Guthrie is located at 36°38′51″N 87°10′15″W / 36.6475°N 87.17083°W / 36.6475; -87.17083 (36.647396, -87.170725).
According to the United States Census Bureau, the city has a total area of 1.4 square miles (3.5 km²), all of it land.