Salyersville is a city in and the county seat of Magoffin County, Kentucky, United States. It is located on the Licking River. The population was 1,604 at the 2000 census.
In 1794 after the American Revolutionary War, the first European-American settlement was attempted by Archibald Prater, John Williams, Ebenezer Hanna, Clayton Cook, but they were driven out by Native Americans who had long inhabited the territory. The pioneer Americans returned six years later in 1800 and built the fort of Licking Station on a hill in the Horse Shoe Bend of the Licking River. This was just outside of present-day city limits.
As the town grew through the decades, it was given the name Adamsville for one of the town founders, "Uncle Billie" Adams. Adams owned extensive farm land, a hotel, a gristmill, a tannery and a blacksmith shop in the area. The area was settled mostly by independent subsistence farming families. Few were slaveholders in eastern Kentucky.