Clayton is a town in northern Concordia Parish, Louisiana, United States. The population was 858 at the 2000 census. Cotton is a principal commodity in the area. Clayton is located on the Tensas River, important for fishing and boating, promoted through a U.S. Army Corps of Engineers-maintained boat launch. The Tensas River merges with the Black River in Jonesville in Catahoula Parish.
Louisiana State Representative John A. "Andy" Anders is from Clayton and Ferriday.
Among the businesses in the community are Cross Keys Bank and David's Grocery.