Mayo is a census-designated place (CDP) in Anne Arundel County, Maryland, United States. The population was 3,153 at the 2000 census. Its beach was formerly a popular weekend resort.
Mayo is located at 38°53′36″N 76°30′16″W / 38.89333°N 76.50444°W / 38.89333; -76.50444 (38.893264, -76.504371).
According to the United States Census Bureau, the CDP has a total area of 4.7 square miles (12.1 km²), of which, 2.5 square miles (6.6 km²) of it is land and 2.2 square miles (5.6 km²) of it (45.94%) is water.