Hughesville is a census-designated place (CDP) in Charles County, Maryland, United States. The population was 1,537 at the 2000 census. Truman's Place was listed on the National Register of Historic Places in 1988.
Hughesville is located at 38°32′1″N 76°46′56″W / 38.53361°N 76.78222°W / 38.53361; -76.78222 (38.533731, -76.782220).
According to the United States Census Bureau, the CDP has a total area of 11.2 square miles (29.0 km²), all of it land.