Greenville is a town in Piscataquis County, Maine, United States. The population was 1,623 at the 2000 census. The town is centered around the lower end of Moosehead Lake, the largest body of fresh water in the state. Greenville is the historic gateway to the north country and a center for outdoor recreation in the area. Greenville High School, with 89 students, was ranked as the third best high school in Maine and one of the top 1,000 in the US in 2010.
First called T9 R10 NWP (or Township 9, Range 10, North of the Waldo Patent), the land was granted about 1812 by the Massachusetts General Court to Thornton Academy in Saco. In 1824, Nathaniel Haskell of Westbrook bought the Thornton Academy Grant. With Oliver Young and John Smith, he began clearing trees that summer for farming near Wilson Pond, where the Wilson Stream would provide water power for mills.
In 1827, Haskell completed a house, and his family joined him. A sawmill was built on Wilson Stream in 1829, with a gristmill added the following year. In 1835, Henry Gower began clearing land beside Moosehead Lake for what would develop into Greenville village. There he erected the first hotel, a two-story building called The Seboomook House, and the first store. On February 6, 1836, Greenville was incorporated from Haskell Plantation, and named for its green forests. By 1846, Greenville village included two houses, two blacksmith shops and a schoolhouse. On August 10, 1848, the town annexed land from Wilson, the remainder of which was distributed to Shirley and Elliotsville.