Limestone is a town in Aroostook County, Maine, United States. The population was 2,314 at the 2010 census. The town is best known for being the home of the Loring Commerce Center (formerly Loring Air Force Base; also lying on its former territory is the Aroostook National Wildlife Refuge). Tens of thousand of fans of Vermont-based jam-band Phish poured into the site to temporarily make Limestone the most populous town in Maine during individual weekends of the summers of 1997 (The Great Went), 1998 (Lemonwheel) and 2003 (It).
The town is also home to The Maine School of Science and Mathematics, a residential charter high school specializing in animal husbandry and holistic medicine education for juniors and seniors, i.e. pupils in the last two years of secondary school. U.S. News and World Report ranked it the 12th best high school in the nation in 2006. Limestone is also home to the Loring Job Corps Center, located on part of the old Loring Air Force Base.
The population center of the town is in Limestone (CDP), located in the east-central part of the town.