Otisville is a village in Genesee County in the U.S. state of Michigan. The population was 882 at the 2000 census. The village is within Forest Township.
According to the United States Census Bureau, the village has a total area of 1.0 square miles (2.5 km²). 0.9 square miles (2.3 km²) of it is land and 0.1 square miles (0.2 km²) of it (9.28%) is water.
As of the census of 2000, there were 882 people, 343 households, and 244 families residing in the village. The population density was 999.1 inhabitants per square mile (387.0/km²). There were 369 housing units at an average density of 418.0 per square mile (161.9/km²). The racial makeup of the village was 96.15% White, 1.02% African American, 0.45% Native American, 0.11% Pacific Islander, 0.57% from other races, and 1.70% from two or more races. Hispanic or Latino of any race were 1.59% of the population.