Risco is a city in New Madrid County, Missouri, United States. The population was 392 at the 2000 census.
Risco started out as a logging town in the late 19th century. At the time, the entire area was covered by swamp.
Risco has a stand alone school district, Risco RII. The school system consists of an elementary school, a combination middle and high school and a gymnasium, all on the same plot of land.