Isle is a city in Mille Lacs County, Minnesota, United States. The population was 751 at the 2010 census. Its name in the Ojibwe language is "Chi-minising" (by the big island), due to being located right by Malone Island of Mille Lacs Lake, the largest island of that lake.
According to the United States Census Bureau, the city has a total area of 2.5 square miles (6.6 km²), of which, 2.1 square miles (5.4 km²) of it is land and 0.4 square miles (1.1 km²) of it (17.32%) is water.
Locally known as the "walleye capital of the world", because of its location on the southeastern shore of beautiful Mille Lacs Lake.