Centralia is a city in Audrain and Boone counties in the U.S. state of Missouri. The population was 3,774 at the 2000 census.
The Boone County portion of Centralia (by far the majority of the city) is part of the Columbia Metropolitan Statistical Area, while the Audrain County portion is part of the Mexico Micropolitan Statistical Area.
Centralia is located at 39°12′35″N 92°8′11″W / 39.20972°N 92.13639°W / 39.20972; -92.13639 (39.209657, -92.136300). According to the United States Census Bureau, the city has a total area of 2.5 square miles (6.6 km²), all land.