Downing is a city in Schuyler County, Missouri, United States. The population was 335 at the 2010 census. It is part of the Kirksville Micropolitan Statistical Area.
Downing is located at 40°29′16″N 92°22′5″W / 40.48778°N 92.36806°W / 40.48778; -92.36806 (40.487682, -92.368022).
According to the United States Census Bureau, the city has a total area of 0.7 square miles (1.7 km²), all of it land.