Farmington is a city in St. Francois County located 60 miles (97 km) south of St. Louis in the Lead Belt region in Missouri in the United States. As of the 2000 U.S. Census, the population was 13,924; a 2008 estimate, however, showed the population to be 16,097. It is the county seat of St. Francois County. The Farmington Micropolitan Statistical Area embraces St. Francois County and Washington County.
Farmington was established in 1822 after its agricultural history and was previously known as Murphy's Settlement for William Murphy of Kentucky who first visited the site in 1798. When St. Francois County was organized, the town was briefly called St. Francois Court House and then later renamed to Farmington.
Farmington is located at 37°46′55″N 90°25′20″W / 37.78194°N 90.42222°W / 37.78194; -90.42222 (37.781932, −90.422145). According to the United States Census Bureau, the city has a total area of 9.0 square miles (23.3 km²), of which, 8.9 square miles (23.2 km²) of it is land and 0.04 square miles (0.1 km²) of it (0.44%) is water.