Galena is a city in Stone County, Missouri, United States. The population was 451 at the 2000 census. It is the county seat of Stone County. Galena is part of the Branson, Missouri Micropolitan Statistical Area.
Galena is located at 36°48′20″N 93°28′2″W / 36.80556°N 93.46722°W / 36.80556; -93.46722 (36.805497, -93.467261). According to the United States Census Bureau, the city has a total area of 0.7 square miles (1.8 km²), all of it land. East of town, the James River flows southerly into Table Rock Lake.
As of the census of 2000, there were 451 people, 165 households, and 121 families residing in the city. The population density was 659.7 people per square mile (256.1/km²). There were 215 housing units at an average density of 314.5 per square mile (122.1/km²). The racial makeup of the city was 98.23% White, 0.22% Asian, 0.22% from other races, and 1.33% from two or more races. Hispanic or Latino of any race were 0.44% of the population.