Jackson is a city in Cape Girardeau County, Missouri, United States. The population was 13,758 at the 2010 census. It is the county seat of Cape Girardeau County. Jackson is named for U.S. President Andrew Jackson. It is a principal city of the Cape Girardeau–Jackson, MO-IL Metropolitan Statistical Area.
Jackson is located at 37°22′48″N 89°39′29″W / 37.38°N 89.65806°W / 37.38; -89.65806 (37.379941, -89.658118). According to the United States Census Bureau, the city has a total area of 10.1 square miles (26.2 km²), of which, 10.1 square miles (26.2 km²) of it is land and 0.10% is water.
As of the census of 2000, there were 11,947 people, 4,708 households, and 3,385 families residing in the city. The population density was 1,180.2 people per square mile (455.8/km²). There were 4,962 housing units at an average density of 490.2 per square mile (189.3/km²). The racial makeup of the city was 96.57% White, 1.36% African American, 0.28% Native American, 0.56% Asian, 0.03% Pacific Islander, 0.19% from other races, and 1.01% from two or more races. Hispanic or Latino of any race were 0.76% of the population.