Kirksville is the county seat of Adair County, Missouri, United States. It is located in Benton Township. The population was 17,505 at the 2010 census. Kirksville also anchors a micropolitan area that comprises Adair and Schuyler counties. The city is perhaps best known as the location of Truman State University and A. T. Still University.
Kirksville is located at 40°11′37″N 92°34′58″W / 40.19361°N 92.58278°W / 40.19361; -92.58278 (40.19368958, -92.58285181). According to the United States Census Bureau, the city has a total area of 10.5 square miles (27.2 km²), of which, 10.5 square miles (27.1 km²) of it is land and 0.04 square miles (0.1 km²) of it (0.38%) is water.
As of the census of 2000, there were 16,988 people, 6,583 households, and 2,975 families residing in the city. The population density was 1,624.0 people per square mile (627.1/km²). There were 7,303 housing units at an average density of 698.2 per square mile (269.6/km²). The racial makeup of the city was 94.38% White, 1.73% African American, 0.26% Native American, 1.93% Asian, 0.04% Pacific Islander, 0.59% from other races, and 1.07% from two or more races. Hispanic or Latino of any race were 1.54% of the population.