Maysville is a city in DeKalb County, Missouri, United States. The population was 1,212 at the 2000 census. It is the county seat of DeKalb County.
Maysville is part of the St. Joseph, MO–KS Metropolitan Statistical Area.
Maysville is located at 39°53′12″N 94°21′36″W / 39.88667°N 94.36°W / 39.88667; -94.36 (39.886720, -94.359973). According to the United States Census Bureau, the city has a total area of 1.1 square miles (3.0 km²), all of it land.