Neosho ( /niːoʊʃoʊ/; originally [nioʒo] or [nioʒu]; officially City of Neosho) is the most populous city in and the county seat of Newton County, Missouri, United States. Neosho is an integral part of the Joplin, Missouri Metropolitan Statistical Area.
Located in southwestern Missouri on the southern edge of the Midwest, Neosho lies at the western edge of the Missouri Ozarks. The population was 10,505 at the time of the 2000 census.
The name "Neosho" is generally accepted to be of Native American (most likely Osage) derivation, meaning "clear, cold water", referring to local freshwater springs. The springs attracted varying cultures of Native American inhabitants for thousands of years. It was also ideal for the later European-American settlers, who founded their style of city in 1833. It was incorporated as a municipal government in 1878. Nicknamed "City of Springs", Neosho has served as an agricultural center and more recently as a National Fish Hatchery. Neosho is known locally as "Gateway to the Ozarks" and, since the 1957, as "the Flower Box City".