Weston is a city in Platte County, Missouri, United States. The population was 1,631 at the 2000 census.
Lewis and Clark Expedition camped out near the location of today's city hall. Weston was the oldest settlement in the Platte Purchase of 1836 and was therefore also the farthest western settlement (thus, "West Town") in the United States until the admission of Texas as a state in 1845. Another suggested origin is related to a story about a discharged US Army dragoon by the name of Joseph Moore. He bought the land and then had First Sergeant Tom Weston of D Company, First Dragoons, stationed at Fort Leavenworth across the Missouri River, lay out a town plan. It is this individual the town is named for.
William Buffalo Bill Cody was at one time a resident of Weston, and the town was a major "jumping off" point for the Santa Fe Trail, the Oregon Trail and the California Gold Rush.