Clarksdale is a city in Coahoma County, Mississippi, United States. The population was 20,645 at the 2000 census. It is the county seat of Coahoma County.
Clarksdale was named in honor of founder and resident John Clark, brother-in-law of politician James Lusk Alcorn, whose plantation home is nearby.
In the early 20th century, Clarksdale was known as the "Golden Buckle in the Cotton Belt" and was home to a multi-cultural mixture of Lebanese, Italian, Chinese and Jewish immigrant merchants along with African-Americans farm laborers and white plantation owners.