Hernando is a city in central DeSoto County, Mississippi. The population was 6,812 at the 2000 census. The 2006 census estimate reflects a population of 10,580. Hernando is the county seat of DeSoto County, the second-most-populous county in the Memphis metropolitan area. US Hwy 51 and the I-55 freeway traverse the entire city from north to south. Hernando's historic downtown square, which surrounds the county courthouse, sits at the intersection of Commerce St. and US-51.
Hernando is located at 34°49′51″N 89°59′37″W / 34.830764°N 89.993614°W / 34.830764; -89.993614.
According to the United States Census Bureau, the city has a total area of 11.4 square miles (30 km2), of which 11.3 sq mi (29 km2) is land, and 0.1 sq mi (0.26 km2) (0.62%) is water.