Pearlington is a census-designated place (CDP) in Hancock County, Mississippi, United States, on U.S. Route 90, along the Pearl River, at the Louisiana stateline. It is part of the Gulfport–Biloxi, Mississippi Metropolitan Statistical Area. The population was 1,684 at the 2000 census. On August 29, 2005, at 10 a.m. Hurricane Katrina made landfall just south of Pearlington.
Pearlington is located at 30°15′0″N 89°36′18″W / 30.25°N 89.605°W / 30.25; -89.605 (30.249994, -89.604939).
According to the United States Census Bureau, the CDP has a total area of 9.6 square miles (24.8 km²), of which, 9.1 square miles (23.6 km²) of it is land and 0.5 square miles (1.2 km²) of it (4.91%) is water.