Pontotoc is a city in Pontotoc County, Mississippi, United States. Pontotoc is west of the much larger city of Tupelo. The population was 5,253 at the 2000 census. It is the county seat of Pontotoc County.
Pontotoc is a Chickasaw word meaning "Land of Hanging Grapes".
The famous outlaws Jesse & Frank James and their notorious gang once hid at an old house which was used as a Union Army hospital during the Battle of Harrisburg or Battle of Tupelo. The house was located at a crossroad in east Pontotoc County, near the Lee County line.