Prentiss is a town in Jefferson Davis County, Mississippi, United States. The population was 1,158 at the 2000 census. It is the county seat of Jefferson Davis County. Prentiss is the hometown of actor Gary Grubbs, NBA player Al Jefferson, and noted software engineer Jeff Lee, as well as the resting place of Steve McNair.
Prentiss is located at 31°35′49″N 89°52′11″W / 31.596990°N 89.869776°W / 31.596990; -89.869776.
According to the United States Census Bureau, the town has a total area of 1.9 square miles (4.8 km²), all of it land.