Ahoskie is a town in Hertford County, North Carolina, United States. The population was 4,523 at the 2000 census. Ahoskie is located in North Carolina's Inner Banks region. Its nickname is "The Only One" because no other town in the world is known by the same name. The origin of the word Ahoskie, which was originally spelled "Ahotsky," came from the Wyanoke Indians who entered the Hertford County area at the beginning of European settlement.
Ahoskie is located at 36°17′11″N 76°59′11″W / 36.28639°N 76.98639°W / 36.28639; -76.98639 (36.286439, -76.986436).
According to the United States Census Bureau, the town has a total area of 2.7 square miles (6.9 km²), all land.