Harrisburg is a census-designated place (CDP) in and the county seat of Banner County, Nebraska, United States. It is part of the Scottsbluff, Nebraska Micropolitan Statistical Area. The population was 75 at the 2000 census.
Harrisburg is located at 41°33′16″N 103°44′25″W / 41.55444°N 103.74028°W / 41.55444; -103.74028 (41.554553, -103.740379).
According to the United States Census Bureau, the CDP has a total area of 5.3 square miles (13.9 km²), all of it land.