Holdrege is a city in Phelps County, Nebraska, United States. The population was 5,636 at the 2000 census. It is the county seat of Phelps County.
Amtrak, the national passenger rail system, provides daily service through Holdrege, operating its California Zephyr daily in both directions between Chicago and Emeryville, California, across the bay from San Francisco.
Holdrege is located at 40°26′26″N 99°22′28″W / 40.44056°N 99.37444°W / 40.44056; -99.37444 (40.440619, -99.374526).