Wayne is a city in Wayne County, Nebraska, United States. The population was 5,660 at the 2010 census. It is the county seat of Wayne County and the home of Wayne State College.
Wayne is located at 42°14′10″N 97°1′1″W / 42.23611°N 97.01694°W / 42.23611; -97.01694 (42.235990, -97.017019).
According to the United States Census Bureau, the city has a total area of 2.2 square miles (5.7 km²), all of it land.