Mosquero is a village in Harding and San Miguel counties in the U.S. state of New Mexico. The population was 120 at the 2000 census. It is the county seat of Harding County; only a small portion of the village extends into San Miguel County.
Mosquero is located at 35°46′35″N 103°57′26″W / 35.77639°N 103.95722°W / 35.77639; -103.95722 (35.776293, -103.957133).
According to the United States Census Bureau, the village has a total area of 1.0 square miles (2.6 km²), all land.