Calypso is a town in Duplin County, North Carolina, United States. The population was 538 at the 2010 census.
Calypso is located at 35°9′17″N 78°6′17″W / 35.15472°N 78.10472°W / 35.15472; -78.10472 (35.154753, -78.104720).
As of the census of 2000, there were 410 people, 178 households, and 111 families residing in the town. The population density was 422.7 people per square mile (163.2/km²). There were 204 housing units at an average density of 210.3 per square mile (81.2/km²). The racial makeup of the town was 71.71% White, 22.93% African American, 0.49% Native American, 0.49% Asian, 3.17% from other races, and 1.22% from two or more races. Hispanic or Latino of any race were 4.39% of the population.