Melville is a hamlet and census-designated place in the town of Huntington in Suffolk County on Long Island, New York, in the United States. As of the 2000 census, 14,533 people resided there.
It is directly east of the county boundary with Nassau County, New York. The Long Island Expressway (LIE) and Northern State Parkway, two of the country's busiest highways and major points of entry in and out of New York City, pass through Melville. Melville is located immediately off of Exit 49 of the LIE. New York State Route 110 runs through the center of Melville.
Melville is home to the U.S. headquarters of several national and international corporations, including Hain Celestial, Arrow Electronics, Chyron, MSC Industrial Direct, Nikon Corporation, OSI Pharmaceuticals, Allion Healthcare, the Italian-food chain Sbarro, the medical and dental supply distributor Henry Schein, Bouchard Transportation and global staffing giant Adecco (US Headquarters). In addition, significant operations of Manhattan-based Estée Lauder are conducted there. Melville is also the host of operations for many Fortune 500 companies. These headquarters and many other corporate and industrial centers are found on or near Route 110, which runs north to south through Huntington, Melville, Farmingdale, North Amityville, and Amityville.