Belpre is a city in Washington County, Ohio, United States, along the Ohio River. It is part of the Parkersburg-Marietta-Vienna, WV-OH Metropolitan Statistical Area. The population was 6,441 at the 2010 census.
The city was also the second settlement in the Northwest Territory after Marietta, located just upriver and today the county seat of Washington County. The town was originally named Belle Prairie or "Beautiful Prairie."
The city is home to the first library established in the Northwest Territory and the first female schoolteacher in Ohio.