Zanesville is a city in and the county seat of Muskingum County, Ohio, United States. The population was 25,586 at the 2000 census.
Zanesville was named after Ebenezer Zane, who had constructed Zane's Trace, a pioneer road through present-day Ohio. He settled in the area in 1797 with his son-in-law, John McIntire, at the point where Zane's Trace met the Muskingum River.
From 1810-1812, the city was the second state capital of Ohio. The National Road runs through Zanesville as U.S. Route 40. Novelist Zane Grey, a descendant of the Zane family, was born in the city.